Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddingsArticle Published on 2023-12-012022-11-15 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] 치료제, [키워드] antiviral properties binding affinity cells Cheminformatics Compound compounds conducted coronavirus dataset dose-dependent inhibition drug design Drug discovery evaluate half-maximal inhibitory concentration in silico inhibitor inhibitory effect ligand-based drug design M pro Machine learning. machine-learning molecular protease Protease inhibitor screened selected thought Toxicity Virtual screening virus infectivity [DOI] 10.1080/14756366.2022.2132486 PMC 바로가기
Highly efficacious and safe neutralizing DNA aptamer of SARS-CoV-2 as an emerging therapy for COVID-19 diseaseArticle Published on 2022-12-302023-07-11 Journal: Virology Journal [Category] COVID19(2023년), [키워드] ACE2 aptamer COVID-19 neutralization RBD Safety SARS-CoV-2 Spike S protein Toxicity virus. VLP [DOI] 10.1186/s12985-022-01943-7 PMC 바로가기
Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell analysisArticle Published on 2022-12-012022-11-15 Journal: Drug Delivery [Category] COVID19(2023년), SARS, 치료제, [키워드] addition administration Analysis Antiviral antiviral activity Calu-3 Cell characterized Concentration COVID-19 cytotoxicity Favipiravir in vitro indicated Influenza virus Inhaled inhaled formulation inhibitor investigated lung lung epithelial cell lung tissue Lungs media Patient patients with COVID-19 PBS phosphate buffer profile pulmonary RdRP real time required respiratory. RNA-dependent RNA polymerase SARS-CoV-2 stability target Toxicity treat Treatment VERO-E6 viability were infected [DOI] 10.1080/10717544.2022.2118398 PMC 바로가기
A SARS-CoV-2 vaccine based on conjugation of SARS-CoV-2 RBD with IC28 peptide and mannanArticle Published on 2022-12-012022-11-15 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 adjuvant Antibody titer Antigen antigenicity Bacterial cause cellular immunity COVID-19 COVID-19 pandemic cytokine develop domain E. coli effective effective vaccine elicit elicited expected expressed feasibility humoral IFN-γ IL-10 IL-5 IMPROVE Interaction Ligand mannan neutralization neutralizing antibody organs peptide polysaccharide RBD RBD-specific IgG SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2. sera severe respiratory disease Th2-type Toxicity Vaccine Vaccine development viral infection virus [DOI] 10.1016/j.ijbiomac.2022.09.180 PMC 바로가기
Photocatalytic degradation of COVID-19 related drug arbidol hydrochloride by Ti3C2 MXene/supramolecular g-C3N4 Schottky junction photocatalystArticle Published on 2022-12-012022-11-15 Journal: Chemosphere [Category] 치료제, [키워드] Affect antiviral drug Arbidol arbidol hydrochloride composed COVID-19 COVID-19 outbreak Degradation drug increasingly less mechanism pathway Photocatalytic degradatiion provide Result resulting Schottky junction SEM significantly superoxide radical Supramolecular g-C(3)N(4) TEM Ti(3)C(2). Toxicity Treatment [DOI] 10.1016/j.chemosphere.2022.136461 PMC 바로가기
Evaluation of degradation performance toward antiviral drug ribavirin using advanced oxidation process and its relations to ecotoxicity evolutionResearch article Published on 2022-12-012022-10-05 Journal: The Science of the total environment [Category] 치료제, [키워드] addition Analysis antiviral drug antiviral drugs applied conditions coronavirus disease Degradation discharged ecosystem Ecotoxicity evaluation effort eliminated Evolution functional Health identify investigated liquid Quantitative ribavirin risk Spread Stage Toxicity Transformation products treated Treatment UV/TiO2/H2O2 process Wastewater treatment [DOI] 10.1016/j.scitotenv.2022.157851 [Article Type] Research article
Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2Article Published on 2022-12-012022-11-16 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, [키워드] affected Analysis ancestor Asymptomatic asymptomatic patients clinical outcomes correlation Degradation deletion of the untranslated region demonstrated Deterioration driving early stage evaluate Evolution explain genetic influence Genome hospitalized patient indicated mathematical Mortality mortality rate Mutation nucleic acid nucleic acid degradation system Patient SARS-CoV-2 SARS-COV-2 infection significantly significantly more similarity strain Support Symptoms the epidemic Toxicity UTR viral genome viral toxicity viral toxicity. virulence virus virus genome was performed [DOI] 10.1080/21505594.2022.2132059 PMC 바로가기
Safety and immunogenicity of the first Kazakh inactivated vaccine for COVID-19Article Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] SARS, 진단, [키워드] adverse effect animal models antibody Antibody titer BALB/c mice changes in class COVID-19 COVID-19 vaccine demonstrated did not produce ELISA ENhance enzyme-linked immunosorbent ferrets Gender general condition GMT group growth hamster hamsters Health histology immune response immunization immunogenicity Inactivated vaccine injection internal organ Kazakhstan lowest microneutralization MNA nontoxic preclinical trials rhesus macaque Safety significant difference statistically significant Toxicity Vaccine vaccine. were assessed [DOI] 10.1080/21645515.2022.2087412 PMC 바로가기
Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
A review on computer-aided chemogenomics and drug repositioning for rational COVID-19 drug discoveryArticle Published on 2022-11-012022-11-15 Journal: Chemical biology & drug design [Category] 변종, 신약개발, 치료기술, 치료제, [키워드] analyzed application assist chemogenomics compounds Computational drug computational drug discovery Computational methods coronavirus coronavirus disease CoV COVID-19 CoVs drug candidate Drug discovery drug repositioning drugs Efficiency epidemic diseases example feasible Host in silico approaches molecular docking other variants outcome Polypharmacology polypharmacology. Protein provide reflected reported Spread therapeutic target time-consuming Toxicity turn unique virus virus [DOI] 10.1111/cbdd.14136 PMC 바로가기